Prof. Kikuo Chishima
Founder of the Society of Neo-Hematology

Foreword by Chishima

I wrote this book as the ninth volume of the ten serial volumes which include my complete works concerned with eight new fundamental and revolutional principles on the biological and medical sciences carried out by me for the past fifty years. And also the practical application of these principles to health, prolongation of life and daily living are included. Furthermore, this book still more contains the scores of my original papers published in English.

But I hope that the persons who wish to know the whole details of my work, will refer to my following serial works: "Chishima´s complete works in Japanese language, regarding biological and medical sciences". (ten volumes, covering more than 5500 pages published in in Japan between 1971 and 1972)

Aims of this Book:

Modern society which lays great emphasis on technological progress and making money, brought us startling material prosperity but lack of wisdom of the ultimate effect abusing them is bringing about many kinds of dangerous chemical pollution on our Earth, and mankind is faced with a critical moment. Moreover, it has changed people into economic animals and kept them at a distance from one another.

If we leave the matter as it is, this material trend will be promoted more and more, and, as a result, our mental decay and physical decline will be promoted more and more, too. It is essential that we should change our way of thinking on the view of value. Now modern material civilization is confronted with a turning-point in history.

We must change our thinking method (scientific methodology or logic) from the materialism, mechanism and formal logic to "bio-dialectic" , designated by the present author, which is a dialectic unifying the body and mind, in other word, unifying material dialectic and spiritual dialectic.

It is generally believed that modern sciences, especially biological and medical sciences have attained to the marvelously advanced state. But we must not overlook the contradiction between the modern medical sciences and diseases. That is to say, the more medical sciences advances, the more patients suffering from incurable chronic diseases such as cancer, heart diseases, apoplexy and so on increase in number.

This suggests that modern Occidental medicine probably has some defects in its principles. According to my opinion, those defects may be attributed to the following two reasons; one is the inadequate thinking of life, that is formal logic, mechanism and materialism are taken. And another is the misunderstanding about blood, especially the origin and function of the red blood corpuscles.

In this book I will present my findings about these problems. Ranging from my first principle to the seventh principle, I will describe the fact that the haematopoietic organ is not the bone marrow but is the intestine villus, and that the red blood corpuscles hold the polypotency of their differentiating into all kind of somatic cells, even into the cancer cells or several other pathologic cells under the pathological conditions.

Even if such a heterodox theory may be considered an incredible one, I believe confidently that it is true, because it is based on positive facts and it coincides with a correct thinking (scientific methodology, bio-dialectic). Recently there appears a new tendency in the field of medical science, not only in Japan but also in Europe and America. This is the revaluation of the Oriental medicine which differs from the Occidental medicine on the following points:

1) Emphasizing the harmony between mind and the body.

2) Laying stress on the wholeness of an organism instead of the analytical thinking.

3) Making more of prevention than treatment.

4) Considering herbs rather than new chemically-synthesized remedies.

5) Putting more value on the natural cure than the artificial remedies and surgical operation for certain chronic diseases.

In this book I intend to unify Oriental and Occidental medicines by picking up the merits, and throwing away the demerits included in them respectively.


I am deeply indebted to my colleagues Prof. F. Tsukiji and Mr. M Saito for their helping in the English translation and proof reading. I am also very grateful to the many persons whose names are described in each paper and monograph published in the past fifty years. I must express my gratitude to Y. Horita and Y. Ito for their encouragement, stimulation and advice to me, by which I have decided to publish this serial book (Chishima´s complete works). Finally, I must express my appreciation to the members of " the Neohematological Society" (superintended by me), and many other persons helping me with my publication.


In the sixteenth century, the discovery of Copernicus that the Earth revolves around the sun evoked a storm of indignation because it displaced the Earth that had been thought to be the center of the universe to the less important position. Namely, the Earth was proved to be only one of the several planets depending on the sun. In these early day such a revolutionary idea was inevitable, thought an insult at the Earth´s chief inhabitants, mankind.

If we read the history of science, we shall find that there are many revolutional discoverings the discoverers of which were exposed to ridicule at first. But if those revolutional findings are correct in both fact and theory, people in the next generation (especially scientists) will gradually come to accept the newly presented heterodox theory. And then the heterodoxy will became the next orthodoxy instead of the present-day one and this history repeats itself.

My findings and opinions are so widely and basically opposed to the orthodox biological and medical sciences that their practical application to human life has a great important meaning. Therefore my new theory may be at first, considered be a curious and doubtful heterodoxy by people. But I believe that if one reexamines it practically or theoretically one will find the that it is true. Now I will mention here the outline of my "eight fundamental and revolutional principles" concerned with biological and medical sciences.

Eight fundamental and revolutional principles

1) The first principle:
Red blood corpuscles with polipotency differentiate into all kinds of somatic cells and germ cells, in accordance with their cellular environmental conditions (milieu)

2) The second principle:
Reversible differentiation between the red blood corpuscles and the fixed cellular elements under the different nutritional conditions or the developmental stages.

3) The third principle:
Bacteria and viruses arise spontaneously from organic matter by means of the AFD process (Aggregation, Fusion and Differentiation).

4) The fourth principle:
Cells increase in number, mainly by the new-formation of them from organic matter but not by the so-called mitotic cell division.

5) The fifth principle:
Haematopoietic organ of the red corpuscle is not the bone marrow but the intestinal villus in the adult and the placental villus in the embryonic stage.

6) The sixth principle:
Orthodox genetics contains some basic mistakes. For instance, according to my finding, the germ cells such as spermatozoa and the ova arise newly from the somatic element, the red blood corpuscles.

7) The seventh principle:
Darwinism involves some important contradictions of the origin of life., the mutation theory, existence of microorganisms (amoebae, bacteria) which remained as they were without evolution, and then the negligence of symbiosis (mutual aid) as an important evolutional factor, etc.

8) The eighth principle:
I have presented a new scientific methodology, bio-dialectic instead of formal logic or material dialectic.
I will describe in the latter chapter of this book the practical application of the above-mentioned eight principles to people´s health and prolongation of life, etc.


Kikuo Chishima was born in Gifu Prefecture Japan on October 10,1899. He became the professor of the Gifu University agricultural department in 1953. He became the professor of the Nagoya Commercial University in 1963. He established the "THE SOCIETY OF NEO-HEMATOLOGY" in 1964. And he died in 1978.


"ACADEMIA" prize ceremony -----------------Prof. Chishima who receives commendation
commemoration in 1968



Photo 1. Microphotograph from a section of Frog's liver injected carbon colloid, showing the transition from erythrocyte into liver cell.
Black mass (a) located in the interstices of liver cells are derivatives from clumps of erythrocytes with carbon colloid. This mass shows transition into Kupffer's cells, from which it differentiates into liver cells (b). There is no sign of typical mitotic Photo in the liver.


Photo 2. Pancreas of mouse and Islet of Langerhans.
There can be seen the continuation and transitional phase from erythrocytes (a) stained with eosin(red) localizing at the upper-right of the fig. into the pale cell-mass (Islet of Langerhans). Islet of Langerhans often contains erythrocytes in it, and it is well-known that the islet cell secrete a hormones (insulin) which play a role to prevent diabetes.
At the circumference of the Islet there are many of dark stained cell-mass (pancreatic acinus). According to my opinion, Islet cells change into acinus cells under well-nourished condition. But under starved condition,the acinus cells change into the Islet cells reversely and at last they return to erythrocytes.


Photo 3. Cancer cells are a derivative from erythrocytes (human uterine cancer) Two blood vessels are descending downward, and their ends are opening to the tissue. Many of erythrocytes are scattering about and they show transition into small-lymphoid elements, immature small cancer cells.B


Photo 4. Human uterine carcinoma.
There can be seen many of extravasate erythrocytes (stained with red) are scattered here and there, and mingled with small primordial cancer cells. And there is transition between these two elements.B


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The Chapters of Chishima's "Revolution of Biology & Medical Science "